Post-ERP pancreatitis as a model for cytokine induced acute phase response in acute pancreatitis.

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Post-ERP pancreatitis as a model for cytokine induced acute phase response in acute pancreatitis.

BACKGROUND/AIMS By contrast with animal models, in most cases it is not possible to examine the systemic response in patients in the first hours after onset of acute pancreatitis. The aim was to determine whether endoscopic retrograde cholangiopancreaticography (ERP)-induced pancreatitis can be used as a human model for the study of cytokine release and acute phase response in the first hours o...

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Acute pancreatitis is a common clinical condition. Excessive systemic inflammatory response syndrome (SIRS) in acute pancreatitis leads to distant organ damage and multiple organ dysfunction syndrome (MODS), which is the primary cause of morbidity and mortality in this condition. Development of in vivo experimental models of acute pancreatitis and associated systemic organ damage has enabled us...

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ژورنال

عنوان ژورنال: Gut

سال: 1997

ISSN: 0017-5749

DOI: 10.1136/gut.40.1.80